Sonarr, sabnzb, plex portability

I am currently using sonarr, sabnzb and plex. All installed on their own drive together (not c drive). All work flawlessly. All media is downloaded to the same drive.

I am looking for portability. Is it possible to install all of these on a USB 3 external drive, run them from the drive on my home pc. Shut it down. Remove the drive and plug it into the pc in my rv and run from there? This way I am taking the programs and the media with me wherever I need to without having to set everything back up.

Ultimately I want to have what I have at home and when I leave for a trip take it with me without missing a beat and without having to take my home pc with me?